B01: Knowledge-based Assistance System for Reconstructive Cardiac Valve Surgery

Reconstructive cardiac valve surgery requires the precise assessment and interpretation of the complex geometry and function of the heart valves. The aim of the project is to create a knowledge-based assistance system, which will continuously provide the surgeon with relevant geometrical and functional knowledge, thereby acting as a new, quantitative decision support tool. 3D parameters will be collected along with pre- and intra-operative clinical parameters. All parameters will be correlated with the postoperative results, transferred into the knowledge base of the TCRC and interpreted by the system.

Project Leaders

Prof. Dr. med. Raffaele De Simone
Prof. Dr. sc. hum. Ivo Wolf

Our Team


De Simone R, Wolf I, Hoda R, Mikhail B, Mottl-Link S, Meinzer H-P, and Hagl S. 2006.

"Three-Dimensional Assessment of Left Ventricular Geometry and Annular Dilatation Provides New Mechanistic Insights into the Surgical Correction of Ischemic Mitral Regurgitation."

The Thoracic and Cardiovascular Surgeon 54 (7): 452–58.


De Simone R, Wolf I, Mottl-Link S, Hoda R, Mikhail B, Sack F-U, Meinzer H-P, and Hagl S. 2006.

"A Clinical Study of Annular Geometry and Dynamics in Patients with Ischemic Mitral Regurgitation: New Insights into Asymmetrical Ring Annuloplasty."

European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Sur-gery 29 (3): 355–61.


Engelhardt S, De Simone R, Wald D, Zimmermann N, Al Maisary S, Beller CJ, Karck M, Meinzer H-P, and Wolf I. 2014.

"Intraoperative Measurements on the Mitral Apparatus Using Optical Tracking: A Feasibility Study."

In SPIE Medical Imaging, 90361L – 90361L. International Society for Optics and Photonics.

Engelhardt S, Graser B, De Simone R, Zimmermann N, Karck M, Meinzer H-P, Nabers D, and Wolf I. 2014.

"Vermessung des Mitralapparats mit einem optisch getrackten Zeigeinstrument für die virtuelle Annuloplastie."

In Bildverarbeitung für die Medizin 2014, edited by T. M. Deserno, H. Handels, H.-P. Meinzer, and T. Tolxdorff, 252–57. Informatik aktuell. Springer Berlin Heidelberg.
(Ausgezeichnet mit dem BVM-Award Best Talk 2014)

Engelhardt S, De Simone R, Zimmermann N, Al-Maisary S, Nabers D, Karck M, Meinzer H-P, and Wolf I. 2014.

"Augmented Reality-Enhanced Endoscopic Images for Annuloplasty Ring Sizing."

In Augmented Environments for Computer-Assisted Interventions, edited by C. A. Linte, Z. Yaniv, P. Fallavollita, P. Abolmaesumi, and D. R. H. III, 128–37. Lecture Notes in Computer Science 8678. Springer International Publishing.
(Ausgezeichnet mit dem Best Paper Award)

Engelhardt S, Lichtenberg N, Al-Maisary S, De Simone R, Rauch H, Roggenbach J, Müller S, Karck M, Meinzer H-P, and Wolf I. 2015.

"Towards Automatic Assessment of the Mitral Valve Coaptation Zone from 4D Ultrasound."

In Functional Imaging and Modeling of the Heart, edited by H. van Assen, P. Bovendeerd, and T. Delhaas, 137–45. Lecture Notes in Computer Sci-ence 9126. Springer International Publishing.

Graser B, Al-Maisary S, Zimmermann N, Nabers D, Meinzer H-P, Wolf I, Karck M, and De Simone R. 2014.

"Computerunterstütztes „ring sizing“ für die Anuloplastie."

Zeitschrift für Herz-,Thorax- und Gefäßchirurgie 28 (5): 347–51.


Graser B, Wald D, Al-Maisary S, Grossgasteiger M, de Simone R, Meinzer H-P, and Wolf I. 2014.

"Using a Shape Prior for Robust Modeling of the Mitral Annulus on 4D Ultrasound Data."

International Journal of Computer Assisted Radiology and Surgery 9 (4): 635–44.


Schoch N, Engelhardt S, Zimmermann N, Speidel S, De Simone R, Wolf I, and Heuveline V. 2015.

"Integration of a Biomechanical Simulation for Mitral Valve Reconstruction into a Knowledge-Based Surgery Assistance System."

In SPIE Medical Imaging, 9415:941502–941502 – 7.