C01: Adaptive Photon Therapy in the Treatment of Lung and Liver Tumours

Tumours of the liver are associated with breath-dependant movements. Thus, the application of precise and conformal radiotherapy presents a major challenge. In order to deliver an exact high dose of radiotherapy in a moving organ, these movements need to be ascertained using an optimized image-based approach. A knowledge base will hereby be generated, which will allow these movements to be predicted, ultimately enabling a dynamic adaption of radiation beam application. This aims to improve the chances of patient cure and reduce side effects.

Project Leaders

Prof. Dr. sc. hum.
Rolf Bendl


Prof. Dr.
Oliver Jäkel


PD Dr. med. 
Florian Sterzing


Our Team


Franz AM, Schmitt D, Seitel A, Chatrasingh M, Echner G, Oelfke U, Nill S, Birkfellner W, Maier-Hein L. 2014.

“Standardized Accuracy Assessment of the Calypso Wireless Transponder Tracking System.”

Physics in Medicine and Biology 59 (22): 6797.


Habermehl D, Henkner K, Ecker S, Jäkel O, Debus J, Combs SE. 2013.

“Evaluation of Different Fiducial Markers for Image-Guided Radiotherapy and Particle Therapy.”

Journal of Radiation Research 54 Suppl 1 (July): i61–68.


Schwarz M, Teske H, Stoll M, Bendl R. 2013.

“Improving Accuracy of Markerless Tracking of Lung Tumours in Fluoroscopic Video by Incorporating Diaphragm Motion.”

In Abstract Book of the International Conference on the Use of Computers in Radiation Therapy, 100.

doi: 10.1088/1742-6596/489/1/012082.

Teske H, Mercea P, Schwarz M, Nicolay NH, Sterzing F, Bendl R. 2015.

“Real-Time Markerless Lung Tumor Tracking in Fluoroscopic Video: Handling Overlapping of Projected Structures.”

Medical Physics 42 (5): 2540–49.


Mercea P, Giske K, Grossmann G, Sterzing F, Bendl R. 2014.

“EP-1673: Automated Detection of Radiopaque Fiducial Markers for Image Registration in MRI-Guided Radiation Therapy.”

In Radiotherapy and Oncology 111: S235-6.

doi: 10.1016/S0167-8140(15)31791-6.

Mercea P, Teske H, Giske K, Bendl R. 2015.

“PD-0464: Adaptive Search Area Template Matching for Image-Based Lung Tumor Tracking.”

Radiotherapy and Oncology 115 (April): S228–29.


Mercea P, Pfaffenberger A, Stoll M, Echner G, Runz A, Gnirs R, Bostel T, Sterzing F, Bendl R. 2015.

“Multi-Modal Image Registration for MR-Guided Radiotherapy Workflow Based on Detection of Features in a Customized Stereotactic Body Frame.”

In World Congress on Medical Physics and Biomedical Engineering 2015.

Saito N, Schmitt D, Bangert M. 2014.

“4D Dose Calculation and Investigation of Repositioning Threshold for Prostate Patients.”

4D Treatment Planning Workshop.

Teske H, Giske K, Bendl R. 2014.

“Localization of Lung Tumors despite Limited Tumor Visibility: Tracking Anatomical Structures in near Proximity to Model the Tumor Motion.”

In 44th Joint Conference of the SSRMP, DGMP, ÖGMP, Dreiländertagung Für Medizinische Physik, 102–3.

Teske H, Mercea P, Giske K, Bendl R. 2015.

“PO-1121: Model Based 2D Localization of Lung Tumors by Incorporating the Motion of Diaphragm.”

Radiotherapy and Oncology 115: S608–9.