R01: Functional Diffusion-Weighted Imaging for Tissue Analysis

Diffusion-weighted, magnetic resonance imaging is a versatile imaging technique, which may yield surrogate markers that represent biological processes, such as tissue perfusion and cellularity, in a non-invasive fashion. In this project, novel diffusion imaging techniques and data evaluation methods will be developed. The techniques developed will be evaluated in terms of lesion differentiation, therapy monitoring and recurrence in patients with pancreatic and liver cancer.

Project Leaders

Prof. Dr. med.
Thilo Hackert

PD Dr. med.
Miriam Klauß

Dr. rer. nat.
Klaus H. Maier-Hein


Our Team


Hauser T, Essig M, Jensen A, Laun FB, Munter M, Maier-Hein KH, and Stieltjes B.

"Prediction of Treatment Response in Head and Neck Carcinomas Using Ivim-Dwi: Evaluation of Lymph Node Metastasis."

European Journal of Radiology 83, no. 5 (2014): 783-87.

doi: 10.1016/j.ejrad.2014.02.013.

Klauss M, Gaida MM, Lemke A, Grunberg K, Simon D, Wente MN, Delorme S, Kauczor HU, Grenacher L, and Stieltjes B.

"Fibrosis and Pancreatic Lesions Counterintuitive Behavior of the Diffusion Imaging-Derived Structural Diffusion Coefficient D."

Investigative Radiology 48, no. 3 (2013): 129-33.

doi: 10.1097/RLI.0b013e31827ac0f1.

Klauss M, Lemke A, Grunberg K, Simon D, Re TJ, Wente MN, Laun FB, Kauczor HU, Delorme S, Grenacher L, and Stieltjes B.

"Intravoxel Incoherent Motion Mri for the Differentiation between Mass Forming Chronic Pancreatitis and Pancreatic Carcinoma."

Investigative Radiology 46, no. 1 (2011): 57-63.

doi: 10.1097/RLI.0b013e3181fb3bf2

Klauss M, Mayer P, Bergmann F, Maier-Hein KH, Hase J, Hackert T, Kauczor HU, Grenacher L, and Stieltjes B.

"Correlation of Histological Vessel Characteristics and Diffusion-Weighted Imaging Intravoxel Incoherent Motion-Derived Parameters in Pancreatic Ductal Adenocarcinomas and Pancreatic Neuroendocrine Tumors."

Investigative Radiology 2015.

doi: 10.1097/RLI.0000000000000187.

Lemke A, Laun FB, Klauss M, Re TJ, Simon D, Delorme S, Schad LR, and Stieltjes B.

"Differentiation of Pancreas Carcinoma from Healthy Pancreatic Tissue Using Multiple B-Values Comparison of Apparent Diffusion Coefficient and Intravoxel Incoherent Motion Derived Parameters."

Investigative Radiology 44, no. 12 (2009): 769-75.

doi: 10.1097/RLI.0b013e3181b62271.

Lemke A, Laun FB, Simon D, Stieltjes B, and Schad LR.

"An in Vivo Verification of the Intravoxel Incoherent Motion Effect in Diffusion-Weighted Imaging of the Abdomen."

Magnetic Resonance in Medicine 64, no. 6 (2010): 1580-85.

doi: 10.1002/mrm.22565.

Lemke A, Stieltjes B, Schad LR, and Laun FB.

"Toward an Optimal Distribution of B Values for Intravoxel Incoherent Motion Imaging."

Magnetic Resonance Imaging 29, no. 6 (2011): 766-76.

doi: 10.1016/j.mri.2011.03.004.

Neher PF, Laun FB, Stieltjes B, and Maier-Hein KH.

"Fiberfox: Facilitating the Creation of Realistic White Matter Software Phantoms."

Magnetic Resonance in Medicine 72, no. 5 (2014): 1460-70.

doi: 10.1002/mrm.25045.

Wetscherek A, Stieltjes B, and Laun FB.

"Flow-Compensated Intravoxel Incoherent Motion Diffusion Imaging."

Magn Reson Med 74, no. 2 (2015): 410-9.

doi: 10.1002/mrm.25410.