R02: Innovative Imaging of Tissue Perfusion

The aim of this project is to develop and establish innovative, functional imaging for tissue analysis by means of dual-energy CT perfusion (DECT). To this end, the new possibilities of tissue analysis based on different spectral X-ray absorption characteristics of different tissue types or tissue states opened up by DECT are to be defined for the visceral organs, such as the pancreas, liver, esophagus and rectum. Furthermore, they will be correlated with clinical and histopathologic parameters. Data acquired will be merged to form a knowledge base and made available for use by the other projects.

Project Leaders

Prof. Dr. med.
Thilo Hackert
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CV

PD Dr. med.
Miriam Klauß
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CV

Dr. sc. hum.
Wolfram Stiller, Dipl.-Phys.

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CV

Our Team

Publications

Stiller W, Skornitzke S, Fritz F, Klauß M, Hansen J, Pahn G, Grenacher L, and Kauczor H-U.

“Correlation of Quantitative Dual-energy CT Iodine Maps and Abdominal CT-perfusion Measurements: Are Single-acquisition DECT Iodine Maps More Than a Reduced-Dose Surrogate of Conventional CT Perfusion?”

Invest Radiol, 50, No. 10 (2015): 703-708.

doi: 10.1097/RLI.0000000000000176.

Nattenmüller J, Hosch W, Nguyen TT, Skornitzke S, Jöres A, Grenacher L, Kauczor H-U, Sommer C, and Stiller W.

“Hypodense liver lesions in patients with hepatic steatosis: Do we profit from dual-energy computed tomography?”

Eur Radiol (2015).

doi: 10.1007/s00330-015-3772-6.

Skornitzke S, Fritz F, Klauß M, Pahn G, Hansen J, Hirsch J, Grenacher L, Kauczor H-U, and Stiller W.

“Qualitative and quantitative evaluation of rigid and deformable motion correction algorithms using dual-energy CT images in view of application to CT perfusion measurements in abdominal organs affected by breathing motion.”

Br J Radiol, 88, No. 1046 (2015): 20140683.

doi: 10.1259/bjr.20140683.

Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, and Büchler MW.

“Advanced-stage pancreatic cancer: therapy options.”

Nat Rev Clin Oncol, 10, No. 6 (2013): 323-333.

doi: 10.1038/nrclinonc.2013.66.

Klauss M, Stiller W, Pahn G, Fritz F, Kieser M, Werner J, Kauczor H-U, and Grenacher L.

“Dual-energy perfusion-CT of pancreatic adenocarcinoma.”

Eur J Radiol, 82, No. 2 (2013): 208-214.

doi: 10.1016/j.ejrad.2012.09.012.

Sommer CM, Schwarzwaelder CB, Stiller W, Schindera ST, Heye T, Stampfl U, Bellemann N, Holzschuh M, Schmidt J, Weitz J, Grenacher L, Kauczor H-U, and Radeleff BA.

“Dual-energy CT-cholangiography in potential donors for living-related liver transplantation: Improved biliary visualization by intravenous morphine co-medication.”

Eur J Radiol, 81, No. 9 (2012): 2007-2013.

doi: 10.1016/j.ejrad.2011.05.016.

Stiller W, Schwarzwaelder CB, Sommer CM, Veloza S, Radeleff BA, and Kauczor H-U.

“Dual-energy, standard and low-kVp contrast-enhanced CT-cholangiography: a comparative analysis of image quality and radiation exposure.”

Eur J Radiol, 81, No. 7 (2012): 1405-1412.

doi: 10.1016/j.ejrad.2011.03.030.

Sommer CM, Schwarzwaelder CB, Stiller W, Schindera ST, Stampfl U, Bellemann N, Holzschuh M, Schmidt J, Weitz J, Grenacher L, Kauczor H-U, and Radeleff BA.

“Iodine removal in intravenous dual-energy CT-cholangiography: Is virtual non-enhanced imaging effective to replace true non-enhanced imaging?”

Eur J Radiol, 81, No. 4 (2012): 692-699.

doi: 10.1016/j.ejrad.2011.01.087.

Klauss M, Stiller W, Fritz F, Kieser M, Werner J, Kauczor H-U, and Grenacher L.

“Computed tomography perfusion analysis of pancreatic carcinoma.”

J Comput Assist Tomogr, 36, No. 2 (2012): 237-242.

doi: 10.1097/RCT.0b013e31824a099e.

Sommer CM, Schwarzwaelder CB, Stiller W, Schindera ST, Heye T, Stampfl U, Ramsauer S, Bellemann N, Weitz J, Schmidt J, Grenacher L, Kauczor H-U, and Radeleff BA.

“Dual-energy computed-tomography cholangiography in potential donors for living-related liver transplantation: initial experience.”

Invest Radiol 45, No. 7 (2010): 406-412.

doi: 10.1097/RLI.0b013e3181dfdabd.