R03: 4D Imaging of Blood Flow and Movement

The movement of organ morphology will be analyzed by multimodality 4D imaging and complemented by a further dimension - blood flow measurement - to achieve 5D-imaging. This will thereby enable the computerized generation of typical and individual organ boundary and blood flow models of the selected vascular system in the heart, aorta, liver, pancreas and rectum. The goal is to integrate these morphological and functional data into an interdisciplinary knowledge base.

Project Leaders

Prof. Dr. med.
Carsten J. Beller

Dr. med.
Fabian Rengier



Beller CJ, Farag M, Wannaku S, Seppelt P, Arif R, Ruhparwar A, Karck M, Weymann A, and Kallenbach K.

"Gender-specific differences in outcome of ascending aortic aneurysm surgery.“

PLoS One. 10(4), (2015): e0124461.

doi: 10.1371/journal.pone.0124461.

Engelhardt S, De Simone R, Wald D, Zimmermann N, Al Maisary S, Beller CJ, Karck M, Meinzer HP, and Wolf I.

“Intraoperative Measurements on the Mitral Apparatus Using Optical Tracking: A Feasibility Study.”

SPIE, 9036:90361L – 90361L – 7, (2014).

doi: 10.1117/12.2043391.

Karmonik C, Müller-Eschner M, Partovi S, Geisbüsch P, Ganten M-K, Bismuth J, Davies MG, et al.

“Computational Fluid Dynamics Investigation of Chronic Aortic Dissection Hemodynamics versus Normal Aorta.”

Vascular and Endovascular Surgery 47, no. 8 (2013): 625–31.


Kratzke J, Schoch N, Weis C, Müller-Eschner M, Speidel S, Farag M, Beller CJ, and Heuveline V.

“Enhancing 4D PC-MRI in an Aortic Phantom Considering Numerical Simulations.”

SPIE, 9412:94121E – 94121E – 8, (2015): doi:10.1117/12.2082483.

Kratzke J, Rengier F, Weis C, Beller CJ, and Heuveline V.

"In vitro flow assessment: from PC-MRI to computational fluid dynamics including fluid-structure interaction.“

SPIE Medical Imaging, 2016. (accepted for publication)

Müller-Eschner M, Kortes N, Rehnitz C, Sumkauskaite M, Rengier F, Böckler D, Kauczor H-U, and Radeleff B.

“Endovascular Repair of a Complex Splenic Artery Aneurysm Using a Multilayer Stent.”

Cardiovascular and Interventional Radiology, (2013).


Müller-Eschner M, Müller T, Biesdorf A, Wörz S, Rengier F, Böckler D, Kauczor H-U, Rohr K, and von Tengg-Kobligk H.

“3D Morphometry Using Automated Aortic Segmentation in Native MR Angiography: An Alternative to Contrast Enhanced MRA?”

Cardiovascular Diagnosis and Therapy 4, no. 2 (2014): 80–87.


Rengier F, Geisbüsch P, Vosshenrich R, Müller-Eschner M, Karmonik C, Schoenhagen P, von Tengg-Kobligk H, and Partovi S.

“State-of-the-Art Aortic Imaging: Part I - Fundamentals and Perspectives of CT and MRI.”

VASA. Zeitschrift Für Gefässkrankheiten 42, no. 6 (2013): 395–412.


Rengier F, Geisbüsch P, Schoenhagen P, Müller-Eschner M, Vosshenrich R, Karmonik C, von Tengg-Kobligk H, and Partovi S.

“State-of-the-Art Aortic Imaging: Part II - Applications in Transcatheter Aortic Valve Replacement and Endovascular Aortic Aneurysm Repair.”

VASA. Zeitschrift Für Gefässkrankheiten 43, no. 1 (2014): 6–26.


Rengier F, Wehrmeister M, Weis C, Leidenberger T, Partovi S, Müller-Eschner M, Vosshenrich R, von Tengg-Kobligk H, Kauczor H-U.

"Magnetic Resonance Imaging of the Aorta and its Application in Aortic Pathologies: Current Standards, Recent Advances and Future Trends.“ RSNA, Chicago, (2015).